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KMID : 0358320080490010012
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Korean Journal of Urology
2008 Volume.49 No. 1 p.12 ~ p.17
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The Expression and Clinical Significance of the Minichromosome Maintenance (MCM) 7 Proliferation Markers in Urothelial Carcinomas of the Bladder
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Maeng Young-Hee
Huh Hee-Jae
Kang Hyun-Wook
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Abstract
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Purpose: The antibodies for minichromosome maintenance(MCM) proteins have been reported as potential proliferative markers and prognostic indicators in various human malignancies. The present study examined the expression pattern of MCM proteins in bladder carcinomas, and we also evaluated their prognostic significance as well as their potential applicability as proliferation markers.
Materials and Methods: Immunohistochemistry for MCM7 and Ki-67 was performed on paraffin sections from 47 cases of bladder carcinoma. The MCM7 and Ki-67 expressions were quantified and then analysis was carried out for determining the association between the expressions of MCM7 and Ki-67 and the clinicopathological parameters.
Results: A significant correlation existed between the expression rate of MCM7 and the histological grade(p＜0.0001). The Ki-67 expression rate was significantly related to the tumor grade(p=0.002) and the pathological stage(p=0.011). On multivariate analysis, MCM7 was not found to be an independent prognostic factor for predicting the recurrence of bladder carcinoma.
Conclusions: The results suggest that MCM is a reliable proliferation marker, but not an independent predictive factor for recurrence of bladder carcinoma.
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KEYWORD
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Transitional cell carcinoma, MCM7 protein, Ki-67
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